Nutrients
Carbohydrates, fats, and proteins from the food you eat.
THE SCIENCE
How your cells make energy, and where the six actives fit in
This page is the long answer. It explains what NAD+ is, where your cells make energy, what tends to change with age, and what each Lujevit ingredient is meant to do. Where the evidence is strong, we say so. Where the evidence is still early, we say that too.
Start here: the molecule every cell runs on
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme, a helper molecule present in every living cell. It carries electrons in the process that converts food into ATP, the cell’s fuel. Enzymes involved in DNA maintenance (PARPs) consume it. Sirtuins, proteins involved in cellular signaling and stress responses, also require it.[3]
Your body makes NAD+ from precursors, forms of vitamin B3 such as nicotinamide riboside (NR). Because NAD+ is constantly used up, supply depends partly on how much precursor is available.
Read the full explainer
Where energy is actually made: the mitochondria
Mitochondria are small structures inside your cells (hundreds to thousands per cell in muscle, heart, and brain) that turn nutrients into ATP. NAD+ is essential to that process, and so is coenzyme Q10, which shuttles electrons along the electron transport chain that generates ATP.[4]
This is the “cellular energy” Lujevit refers to. It’s not a stimulant effect. Caffeine changes how alert you feel. It doesn’t change how much ATP your cells produce.
Mitochondria
Tiny structures inside your cells that turn those nutrients into usable energy.
ATP
The fuel every cell runs on, powering everything from your heartbeat to your thoughts.
Simplified view of how your cells turn food into energy.[4]
Three things that tend to change in your cells after 40
NAD+ availability
Studies report lower NAD+ levels with age in several human tissues, along with higher activity of the enzymes that consume it.[5] The exact extent of the decline varies by tissue and measurement method. That’s why we don’t quote a percentage.
Related active: nicotinamide riboside
Oxidative stress
Normal metabolism produces reactive molecules (free radicals). The body’s antioxidant defenses handle them, but the balance can shift with age.[6]
Related actives: quercetin phytosome, trans-resveratrol, pterostilbene
Cellular cleanup (autophagy)
Autophagy is the process cells use to break down and recycle damaged components. It tends to become less efficient with age. Spermidine induces autophagy in cell and animal models.[7]
Related active: spermidineSix actives and what they do
| Active | What it does | Per serving |
|---|---|---|
| Nicotinamide Riboside (as chloride) | NAD+ precursor, shown to raise NAD+ levels[1][2] | 500 mg |
| Quercetin Phytosome | Antioxidant support, in a form chosen for better absorption[8] | 250 mg |
| Trans-Resveratrol | Antioxidant support, the most-studied form of resveratrol | 150 mg |
| Coenzyme Q10 | Supports mitochondrial energy production*[4] | 100 mg |
| Pterostilbene | Antioxidant support, with high bioavailability[9] | 50 mg |
| Spermidine (as HCl) | Supports your cells’ natural renewal process (autophagy)*[7] | 10 mg |
Every ingredient explained in depthDo NAD+ supplements work? What the evidence says
Well established
Oral NR is well tolerated and reliably raises blood NAD+ levels in adults, including middle-aged and older adults, in randomized trials.[1][2] Quercetin phytosome is absorbed far better than standard quercetin.[8] Spermidine induces autophagy in cells and animals.[7]
Promising, not settled
Trials have shown mixed results on whether raising NAD+ leads to measurable changes in energy, metabolism, or cardiovascular markers. Long-term studies with clinical outcomes are still missing.[10]
Not shown
No supplement, including Lujevit, has been shown to reverse aging, treat any disease, or improve memory or focus. We don’t make those claims.
Our position: use well-studied ingredients at research-backed doses, be honest about what’s still unknown, and let you decide with a 30-day guarantee.
Why we talk about women over 40 specifically
Most of the women we hear from are between 40 and 60, and they describe the same thing: sleeping enough and still waking up tired, a mid-afternoon slump, and a counter full of bottles. We wrote a page for that.
NAD+ for women over 40
Putting it together
A precursor to support NAD+ production. CoQ10 to help maintain the mitochondria that use it. Three plant antioxidants to promote the body’s defenses against oxidative stress. Spermidine supports the renewal process that keeps cells tidy. Take two capsules once a day with your first meal.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
References
- 1. Trammell SA et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 2016.
- 2. Martens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications, 2018.
- 3. Covarrubias AJ et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol, 2021.
- 4. Hernández-Camacho JD et al. Coenzyme Q10 supplementation in aging and disease. Front Physiol, 2018.
- 5. McReynolds MR et al. Age-related NAD+ decline. Exp Gerontol, 2020.
- 6. Pizzino G et al. Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev, 2017.
- 7. Eisenberg T et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol, 2009.
- 8. Riva A et al. Improved oral absorption of quercetin from Quercetin Phytosome®. Eur J Drug Metab Pharmacokinet, 2019.
- 9. Kapetanovic IM et al. Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemother Pharmacol, 2011.
- 10. Freeberg KA et al. Dietary supplementation with NAD+-boosting compounds in humans: current knowledge and future directions. J Gerontol A Biol Sci Med Sci, 2023.
- 11. Nguyen AT, Nguyen B. Mapping evidence gap between NMN and NR for metabolic outcomes: a systematic review, transitivity assessment, and indirect comparison meta-analysis. bioRxiv (preprint), 2026.